Advanced Pharmacology Exam

Advanced Pharmacology Exam

 

Question 1.1. Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to: (Points : 1)

a. A need to monitor drugs metabolized by 2D6 for toxicity

b.Increased dosages needed of drugs metabolized by 2D6, such as the SSRIs

c. Decreased conversion of codeine to morphine by CYP 2D6

d.The need for lowered dosages of drugs, such as beta blockers

Question 2.2. Rifampin is a nonspecific CYP450 inducer that may: (Points : 1)

a.Lead to toxic levels of rifampin and must be monitored closely

b.Cause toxic levels of drugs, such as oral contraceptives, when co-administered

c.Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure

d. Cause nonspecific changes in drug metabolism

Question 3.3. Inhibition of P-glycoprotein by a drug such as quinidine may lead to: (Points : 1)

a.Decreased therapeutic levels of quinidine

b. Increased therapeutic levels of quinidine

c.Decreased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination

d. Increased levels of a co-administered drug, such as digoxin, that requires P-glycoprotein for absorption and elimination

Question 4.4. Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: (Points : 1)

a. Toxic levels of warfarin building up

b.Decreased response to warfarin

c.Increased risk for significant drug interactions with warfarin

d.Less risk of drug interactions with warfarin

Question 5.5. Pharmacogenetic testing is required by the Food and Drug Administration (FDA) prior to prescribing: (Points : 1)

a. Erythromycin

b.Digoxin

c. Cetuximab

d.Rifampin

Question 6.6. Patients who have a poor metabolism phenotype will have: (Points : 1)

a.Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug

b.Accumulation of inactive metabolites of drugs

c.A need for increased dosages of medications

d. Increased elimination of an active drug

Question 7.7. Ultra-rapid metabolizers of drugs may have: (Points : 1)

a. To have dosages of drugs adjusted downward to prevent drug accumulation

b.Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure

c.Increased elimination of active, nonmetabolized drug

d. Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug

Question 8.8. When melatonin is used to induce sleep, the recommendation is the patient: (Points : 1)

a.Take 10 mg 30 minutes before bed nightly

b.Take 1 to 5 mg 30 minutes before bed nightly

c.Not take melatonin more than three nights a week

d. Combine melatonin with zolpidem (Ambien) for the greatest impact on sleep

Question 9.9. Valerian tea causes relaxation and can be used to help a patient fall asleep. Overdosage of valerian (more than 2.5 gm/dose) may lead to: (Points : 1)

a.Cardiac disturbances

b.Central nervous system depression

c.Respiratory depression

d.Skin rashes

Question 10.10. The standard dosage of St John’s Wort for the treatment of mild depression is: (Points : 1)

a. 300 mg daily

b. 100 mg three times a day

c.300 mg three times a day

d. 600 mg three times a day

Question 11.11. Licorice root is a common treatment for dyspepsia. Drug interactions with licorice include: (Points : 1)

a.Antihypertensives, diuretics, and digoxin

b.Antidiarrheals, antihistamines, and omeprazole

c.Penicillin antibiotic class and benzodiazepines

d.None of the above

Question 12.12. Patients should be warned about the overuse of topical wintergreen oil to treat muscle strains, as overapplication can lead to: (Points : 1)

a.Respiratory depression

b.Cardiac disturbance

c.Salicylates poisoning

d.Life-threatening rashes

Question 13.13. The role of the NP in the use of herbal medication is to: (Points : 1)

a.Maintain competence in the prescribing of common herbal remedies      b.Recommend common over-the-counter herbs to patients

c.Educate patients and guide them to appropriate sources of care       d.Encourage patients to not use herbal therapy due to the documented dangers

Question 14.14. According to Traditional Chinese Medicine, if a person who has a fever is given an herb that is cooling in nature, such as golden seal, the patient’s illness will: (Points : 1)

a. Get worse

b.Get better

c.Not be adequately treated

d.Need additional herbs to treat the yang

Question 15.15. Michael asks you about why some drugs are over-the-counter and some are prescription. You explain that in order for a drug to be approved for over-the-counter use the drug must: (Points : 1)

a. Be safe and labeled for appropriate use

b.Have a low potential for abuse or misuse

c.Be taken for a condition the patient can reliably self-diagnose

d.All of the above

Question 16.16. In the United States, over-the-counter drugs are regulated by: (Points : 1)

a. No one, there is no oversight for over-the-counter medications

b.The U.S. Food and Drug Administration Center for Drug Evaluation and Research

c.The Drug Enforcement Administration

d.MedWatch

Question 17.17. As drugs near the end of their patent, pharmaceutical companies may apply for the drug to change to over-the-counter status in order to: (Points : 1)

a.Get a new patent for the over-the-counter form of the drug

b.Lower the costs, since most prescription benefit plans do not cover generics

c.Market the drug to a whole new population, as they are able to market to patients instead of just providers

d.Continue to make large profits from their blockbuster brand-name drug

Question 18.18. When obtaining a drug history from Harold, he gives you a complete list of his prescription medications. He denies taking any other drugs, but you find that he occasionally takes aspirin for his arthritis flare ups. This is an example of: (Points : 1)

a.His appropriately only telling you about his regularly prescribed medications

b.His hiding information regarding his inappropriate use of aspirin from you

c.A common misconception that intermittently taken over-the counter medications are not an important part of his drug history

d.A common misuse of over-the-counter aspirin

Question 19.19. When prescribing a tetracycline or quinolone antibiotic it is critical to instruct the patient: (Points : 1)

a.Not to take their regularly prescribed medications while on these antibiotics

b. Regarding the need for lots of acidic foods and juices, such as orange juice, to enhance absorption

c.Not to take antacids while on these medications, as the antacid decreases absorption

d.That there are no drug interactions with these antibiotics

Question 20.20. Sadie’s adult daughter reports that when Sadie (age 84 years) takes Tylenol PM (acetaminophen and diphenhydramine) to help her sleep she has “strange dreams” including wandering and thinking she is at her childhood home. You understand: (Points : 1)

a.This is a sign of early dementia and she should undergo cognitive testing   b.Sadie is not taking an effective dose to help her stay asleep

c.Sadie is exhibiting signs of an allergic reaction to the diphenhydramine in the Tylenol PM

d.Delirium is a common adverse reaction seen when elderly patients take diphenhydramine

Important information for writing discussion questions and participation

Welcome to class

Hello class and welcome to the class and I will be your instructor for this course. This is a -week course and requires a lot of time commitment, organization, and a high level of dedication. Please use the class syllabus to guide you through all the assignments required for the course. I have also attached the classroom policies to this announcement to know your expectations for this course. Please review this document carefully and ask me any questions if you do. You could email me at any time or send me a message via the “message” icon in halo if you need to contact me. I check my email regularly, so you should get a response within 24 hours. If you have not heard from me within 24 hours and need to contact me urgently, please send a follow up text to

I strongly encourage that you do not wait until the very last minute to complete your assignments. Your assignments in weeks 4 and 5 require early planning as you would need to present a teaching plan and interview a community health provider. I advise you look at the requirements for these assignments at the beginning of the course and plan accordingly. I have posted the YouTube link that explains all the class assignments in detail. It is required that you watch this 32-minute video as the assignments from week 3 through 5 require that you follow the instructions to the letter to succeed. Failure to complete these assignments according to instructions might lead to a zero. After watching the video, please schedule a one-on-one with me to discuss your topic for your project by the second week of class. Use this link to schedule a 15-minute session. Please, call me at the time of your appointment on my number. Please note that I will NOT call you.

Please, be advised I do NOT accept any assignments by email. If you are having technical issues with uploading an assignment, contact the technical department and inform me of the issue. If you have any issues that would prevent you from getting your assignments to me by the deadline, please inform me to request a possible extension. Note that working fulltime or overtime is no excuse for late assignments. There is a 5%-point deduction for every day your assignment is late. This only applies to approved extensions. Late assignments will not be accepted.

If you think you would be needing accommodations due to any reasons, please contact the appropriate department to request accommodations.

Plagiarism is highly prohibited. Please ensure you are citing your sources correctly using APA 7th edition. All assignments including discussion posts should be formatted in APA with the appropriate spacing, font, margin, and indents. Any papers not well formatted would be returned back to you, hence, I advise you review APA formatting style. I have attached a sample paper in APA format and will also post sample discussion responses in subsequent announcements.

Your initial discussion post should be a minimum of 200 words and response posts should be a minimum of 150 words. Be advised that I grade based on quality and not necessarily the number of words you post. A minimum of TWO references should be used for your initial post. For your response post, you do not need references as personal experiences would count as response posts. If you however cite anything from the literature for your response post, it is required that you cite your reference. You should include a minimum of THREE references for papers in this course. Please note that references should be no more than 5 years old except recommended as a resource for the class. Furthermore, for each discussion board question, you need ONE initial substantive response and TWO substantive responses to either your classmates or your instructor for a total of THREE responses. There are TWO discussion questions each week, hence, you need a total minimum of SIX discussion posts for each week. I usually post a discussion question each week. You could also respond to these as it would count towards your required SIX discussion posts for the week.

I understand this is a lot of information to cover in 5 weeks, however, the Bible says in Philippians 4:13 that we can do all things through Christ that strengthens us. Even in times like this, we are encouraged by God’s word that we have that ability in us to succeed with His strength. I pray that each and every one of you receives strength for this course and life generally as we navigate through this pandemic that is shaking our world today. Relax and enjoy the course!

Hi Class,

Please read through the following information on writing a Discussion question response and participation posts.

Contact me if you have any questions.

Important information on Writing a Discussion Question

  • Your response needs to be a minimum of 150 words (not including your list of references)
  • There needs to be at least TWO references with ONE being a peer reviewed professional journal article.
  • Include in-text citations in your response
  • Do not include quotes—instead summarize and paraphrase the information
  • Follow APA-7th edition
  • Points will be deducted if the above is not followed

Participation –replies to your classmates or instructor

  • A minimum of 6 responses per week, on at least 3 days of the week.
  • Each response needs at least ONE reference with citations—best if it is a peer reviewed journal article
  • Each response needs to be at least 75 words in length (does not include your list of references)
  • Responses need to be substantive by bringing information to the discussion or further enhance the discussion. Responses of “I agree” or “great post” does not count for the word count.
  • Follow APA 7th edition
  • Points will be deducted if the above is not followed
  • Remember to use and follow APA-7th edition for all weekly assignments, discussion questions, and participation points.
  • Here are some helpful links
  • The is a great resource

 

 

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